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. 2020 Jun 29;117(28):16391–16400. doi: 10.1073/pnas.2002499117

Fig. 1.

Fig. 1.

MBNL1 is down-regulated in cancer and is a prognostic marker for survival. (A) Box plot showing median difference in variance stabilized transformed read counts (VST counts) for MBNL1. Each shaded circle (red, up-regulated; blue, down-regulated) represents a unique patient. Down-regulated indicated in red font, up-regulated by green font (log2 fold change >0.5 (abs), P value <0.05) and no change in black font. (B) The table lists number (N) of patients with higher or lower MBNL1 expression in matched tumors/normal. (C) Representative MBNL1 expression (IHC) in matched tumor and normal stomach adenocarcinoma patients in a tissue microarray (TMA). (D) Western blot showing MBNL1 expression. (E) Kaplan–Meier plots showing correlation between MBNL1 and overall survival. (F and G) Kaplan–Meier plots showing correlation between MBNL1 expression and “relapse-free survival” and “distant-metastasis-free survival.”