Table 1.

Top 10 metabolites with marked up-regulation or down-regulation during malignant progression from HC to OSCC

Metabolites	PML vs. HC		OSCC vs. PML		OSCC vs. HC
	FDR adjusted P value*	Fold change†	FDR adjusted P value*	Fold change†	FDR adjusted P value*	Fold change†
Putrescine	0.0075	2.22	0.0000	2.50	0.0000	5.53
Cadaverine	0.0006	4.10	0.0056	5.51	0.0010	22.56
Thymidine	0.0671	2.55	0.0000	4.12	0.0000	10.51
Adenosine	0.2160	3.74	0.0000	12.96	0.0000	48.47
5-aminopentoate	0.6101	1.21	0.0000	6.60	0.0000	7.97
Hippuric acid	0.1266	0.58	0.0006	0.35	0.0008	0.20
Phosphocholine	0.0000	0.48	0.0000	0.36	0.0000	0.17
Glucose	0.0558	0.39	0.0091	0.11	0.0002	0.04
Serine	0.3830	0.79	0.0000	0.07	0.0000	0.05
Adrenic acid	0.0832	0.54	0.0000	0.07	0.0000	0.04

^*FDR: false discovery rate, which was calculated according to the Benjamini–Hochberg method.

^†Fold changes were calculated by the mean intensities ratio of PML/HC, OSCC/PML, and OSCC/HC.