TABLE 2.

Statin treatment: agents, dose, indication for use and reported AEs during statin use

ID a	Agent	Dose (mg/d)	Indication	Duration on statin after IIM diagnosis (months)	AEs (presumed cause b )
1	Atorvastatin/Pravastatin/Rosuvastatin	20/80/5	HLD	61	Elevated liver enzymes (PBC flare), nausea (unknown), diarrhea (unknown)
2	Rosuvastatin c	20	HTN, diabetes	70	Nausea(MMF)
3	Simvastatin	40	Diabetes, HTN, AAA s/p repair	90	Elevated liver enzymes (antibiotics), elevated Cr (hypovolemia)
4	Lovastatin/Atorvastatin c	40/40	CAD s/p PCI	99
5	Rosuvastatin c	20	HLD	108
6	Pravastatin	20	HLD	90	Elevated liver enzymes (MMF)
7	Rosuvastatin	10	HLD	27
8	Atorvastatin	10	CAD, HLD, HTN	21
9	Atorvastatin	10	HLD	84
10	Rosuvastatin	10	HTN	71	Tendonitis (unknown), abdominal pain (interstitial cystitis)
11	Atorvastatin	10	diabetes, HTN	2	Elevated liver enzymes/renal failure (hemorrhagic shock)
12	Atorvastatin	20	HLD	47	Abdominal cramps (cyclophosphamide)
13	Atorvastatin	10	TIA/lacunar infarct	7	Diarrhea (unknown), dizziness (MMF), Myalgia (statin)
14	Atorvastatin c	40	CVA with carotid artery occlusion	77	Diarrhea(MMF)
15	Atorvastatin c	40	CAD s/p PCI	30
16	Atorvastatin c	40	CVA, DM, HTN	42
17	Rosuvastatin	5	HLD	27
18	Rosuvastatin c	40	HLD, CAD, carotid atherosclerosis	43
19	Rosuvastatin	5	HTN, HLD	3	Tendonitis
20	Atorvastatin	10	HLD	9
21	Atorvastatin	10	cardiomyopathy, CHF	29	Elevated liver enzymes/nausea (cyclophosphamide)
22	Pravastatin	20	cardiomyopathy s/p transplant	32	Muscle spasms of neck/abdomen (post heart transplant, surgical site complication)
23	Atorvastatin	20	HLD	48	Abdominal pain(biliary colic)
24	Atorvastatin	5/10	N/A	14
25	Atorvastatin	N/A	N/A	0	Myalgia (statin)
26	Simvastatin/Pravastatin	40/80	HLD	0	Myalgia, weakness (simvastatin)
27	Atorvastatin	10	CAD, diabetes, HTN	0	Onset of necrotizing myopathy
28	Atorvastatin	N/A	N/A	0	Onset of necrotizing myopathy
29	Atorvastatin c	40	Diabetes, HTN, HLD	0	Onset of necrotizing myopathy
30	Atorvastatin	20	Diabetes, HTN, HLD	0	Onset of necrotizing myopathy
31	Atorvastatin	20	CVD, Diabetes	N/A	N/A
32	Atorvastatin	N/A	HLD	N/A	N/A
33	Atorvastatin c	40	HLD	N/A	N/A

Abbreviations: AEs, adverse events; MMF, mycophenolate mofetil; N/A, data not available; PBC, primary biliary cirrhosis.

^aPatients 24 to 30 are in prior statin group, 31 to 33 are patients without follow‐up data (excluded from statin group for lack of disease activity assessment).

^bPresumed cause: based on temporal correlation of adverse event with onset or dose/change of medication or clinical event.

^cHigh intensity statin include Atorvastatin 40 to 80 mg, rosuvastatin 20 to 40 mg.

Bold values are high intensity statin.