Table 1.
Functional output values of computational porcine models compared to in vivo recorded values.
| Subjects | IN SILICO LV≡ EDV† (mL) | IN VIVO LV EDV (mL) | EDV% of IN VIVO | IN SILICO LV ESV‡ (mL) | IN VIVO LV ESV (mL) | ESV% of IN VIVO | IN SILICO SV†† (mL) | IN VIVO SV (mL) | SV% of IN VIVO | IN SILICO EF*(%) | IN VIVO EF (%) | EF% of IN VIVO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NC 1 | 73.9 | 72.6 | 102% | 35.1 | 34.7 | 101% | 38.8 | 37.9 | 102% | 52.5% | 52.2% | 101% |
| NC 2 | 59.8 | 59.2 | 101% | 26.5 | 27.0 | 98% | 33.2 | 32.2 | 103% | 55.6% | 54.4% | 102% |
| NC 3 | 69.4 | 68.1 | 102% | 36.6 | 36.0 | 102% | 32.8 | 32.1 | 102% | 47.2% | 47.1% | 100% |
| NC 4 | 81.0 | 83.4 | 97% | 42.4 | 42.9 | 99% | 38.7 | 40.5 | 95% | 47.7% | 48.6% | 98% |
| NC 5 | 75.0 | 76.1 | 99% | 41.8 | 41.5 | 101% | 33.2 | 34.6 | 96% | 44.3% | 45.5% | 97% |
| NC** mean | 71.8 ± 7.1 | 71.9 ± 8.1 | 35.3 ± 2.8 | 35.5 ± 3.3 | 49.5 ± 4.1 | 49.6 ± 3.3 | ||||||
| 99.9 ± 1.9 | 36.5 ± 5.7 | 36.4 ± 5.7 | 100.1 ± 1.4 | 99.6 ± 3.4 | 99.8 ± 1.8 | |||||||
| HFC 1 | 77.3 | 78.8 | 98% | 52.5 | 53.8 | 98% | 24.8 | 25.0 | 99% | 32.0% | 31.7% | 101% |
| HFC 2 | 99.8 | 103.0 | 97% | 67.7 | 70.0 | 97% | 32.1 | 33.0 | 97% | 32.2% | 32.0% | 100% |
| HFC 3 | 96.1 | 94.8 | 101% | 63.8 | 62.4 | 102% | 32.2 | 32.4 | 99% | 33.6% | 34.2% | 98% |
| HFC 4 | 94.9 | 94.4 | 101% | 58.3 | 57.9 | 101% | 36.6 | 36.5 | 100% | 38.6% | 38.7% | 100% |
| HFC 5 | 66.3 | 67.0 | 99% | 41.7 | 42.2 | 99% | 24.5 | 24.8 | 99% | 37.0% | 37.0% | 100% |
| HFC§ mean | 99.2 ± 2.0 | 30.1 ± 4.7 | 30.3 ± 4.7 | 34.7 ± 2.7 | 34.7 ± 2.7 | |||||||
| 86.9 ± 12.9 | 87.6 ± 12.9 | 99.2 ± 1.6 | 56.8 ± 9.1 | 57.3 ± 9.3 | 99.1 ± 1.0 | 99.9 ± 1.0 | ||||||
| HFI 1 | 110.2 | 113.3 | 97% | 63.8 | 65.6 | 97% | 46.4 | 47.7 | 97% | 42.1% | 42.1% | 100% |
| HFI 2 | 135.5 | 134.4 | 101% | 70.9 | 70.0 | 101% | 64.6 | 64.4 | 100% | 47.7% | 47.9% | 100% |
| HFI 3 | 79.7 | 77.0 | 103% | 46.2 | 44.9 | 103% | 33.5 | 32.1 | 104% | 42.0% | 41.7% | 101% |
| HFI 4 | 124.6 | 126.5 | 99% | 66.1 | 68.2 | 97% | 58.5 | 58.3 | 100% | 46.9% | 46.1% | 102% |
| HFI 5 | 119.8 | 121.7 | 98% | 71.0 | 71.0 | 100% | 48.8 | 50.6 | 96% | 40.7% | 41.6% | 98% |
| HFI‖ mean | 99.5 ± 2.3 | 50.4 ± 10.7 | 50.6 ± 11 | 43.9 ± 2.8 | 43.9 ± 2.6 | 100 ± 1.3 | ||||||
| 114 ± 19.0 | 114.6 ± 20 | 99.5 ± 2.2 | 63.6 ± 9.1 | 63.9 ± 9.7 | 99.5 ± 2.8 |
*
EF ejection fraction
†
EDV = End-diastolic volume
‡
ESV = End-systolic volume.
§
HFC = Heart failure control.
‖
HFI = Heart failure injected.
≡
LV = Left ventricle.
**
NC = Normal control.
††
SV = Stroke volume.