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. 2020 Jun 3;35(7):1685–1692. doi: 10.1093/humrep/deaa082

Table II.

Frequency of pregnancies and relative risk of ectopic pregnancies between women with and without a benzodiazepine prescription.

Exposure Had a benzodiazepine prescription Did not have any benzodiazepine prescriptions Risk differenceb (95% CI) Relative risk (95% CI)
N Eventsa (Riskb) N Eventsa (riskb) Crude IPT-weightedb
Any benzodiazepine 17 990 462 (257) 1 673 376 29 584 (177) 80 (57, 103) 1.45 (1.33, 1.59) 1.47 (1.32, 1.63)d
Specific benzodiazepine c
 Alprazolam 9261 237 (256) 1 682 105 29 809 (177) 79 (46, 111) 1.44 (1.27, 1.64) 1.51 (1.31, 1.73)e
 Clonazepam 5527 126 (228) 1 685 839 29 920 (177) 50 (11, 90) 1.28 (1.08, 1.53) 1,19 (0.96, 1.48)f
 Lorazepam 3568 93 (261) 1 687 798 29 953 (177) 83 (31, 135) 1.47 (1.20, 1.80) 1.51 (1.20, 1.90)g
 Diazepam 1847 55 (298) 1 689 519 29 991 (178) 120 (43, 198) 1.68 (1.29, 2.18) 1.49 (1.08, 2.07)h

Abbreviations: IPT = inverse probability of treatment

a

aNumber of ectopic pregnancies

b

bPer 10 000 pregnancies

c

cWomen can have a prescription for more than one type of benzodiazepine

d

dSee Supplementary Table SIII for unweighted and IPT-weighted standardized differences of baseline characteristics

e

eSee Supplementary Table SIV for unweighted and IPT-weighted standardized differences of baseline characteristics

f

fSee Supplementary Table SV for unweighted and IPT-weighted standardized differences of baseline characteristics

g

gSee Supplementary Table SVI for unweighted and IPT-weighted standardized differences of baseline characteristics

h

hSee Supplementary Table SVII for unweighted and IPT-weighted standardized differences of baseline characteristics