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. 2020 Jul 3;35(7):1515–1528. doi: 10.1093/humrep/deaa101

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© The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Study design. A hybrid research was conducted to investigate which semen/hormone biomarker was associated with circadian desynchrony. (i) A cross-sectional study of 1346 men was used to analyse the association between semen/hormone biomarkers and work-related circadian desynchrony. (ii) A cohort of 796 undergraduates was used to analysed the association between semen/hormone biomarkers and non-work-related circadian desynchrony. (iii) The biomarker which was identified to be associated with circadian desynchrony simultaneously in both populations was further validated in mouse model.