Table II.
Intrafollicular levels of AMH, VEGF and estrogens metabolites (EMs) in antral and dominant follicle of normal women with spontaneous cycles and PCOS women with follicular arrest.
| Ovulatory (n = 10) (antral follicle) | PCOS (n = 10) (antral follicle) | Ovulatory (n = 10) (dominant follicle) | |
|---|---|---|---|
| Age (year) | 32.6 ± 1.14 | 29.6 ± 3.0 | 33.1 ± 2.0 |
| AMH (ng/ml)* | 213.2 ± 28.0 | 546.3 ± 16.7a | 2.9 ± 0.09b |
| VEGF (pg/ml)* | 503.2 ± 101.40 | 33.1 ± 5.9a | 6529.6 ± 514.3b |
| ∑ EMs pro-angiogenic (2-OHE2 + 4-OHE1 + 16-KE2) (ng/ml) | 1099.7 ± 128.1 | 441.9 ± 31.8a | 3658.5 ± 278.0b |
| ∑ EMs anti-angiogenic (2-ME2 + 2-ME1) (ng/ml) | 689.25 ± 111.4 | 1239.3 ± 177.7 | 3159.8 ± 604.3b |
| ∑ Pro-angio/∑ Anti-angio ratio | 1.59 | 0.35a | 1.15 |
| Follicular diameter (mm) | <10 | <10 | >16 |
a
Comparing the difference between antral follicles of ovulatory and PCOS women (P < 0.05). Values are mean ± SEM.
b
Comparing the difference between antral and dominant follicles of ovulatory women (P < 0.05). Values are mean ± SEM.
*
AMH and VEGF determination correspond to n = 17 FF samples of PCOS.
∑ EMs, sum of estrogen metabolites; VEGF, vascular endothelial growth factor.