Figure 3.

Representative Connections between Clade-Gene-Drug-Condition

(A) Sankey diagram of the genes that are co-evolved with ACE2 in four clades and the drugs targeting them.

(B) A subnetwork of ACE2 highlighting the genes with drug repositioning options. Node fill colors indicate subgroup affiliations inside the network: genes related to inflammation, drug metabolism, glucose metabolism, and vasodilators. Edge stroke colors represent six types of experimental evidence of the protein-protein interactions.

See also Table S4.