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Frequency of HLA-DRB1*04:01 that allows binding of the ORF8 variant epitope. Based on previous studies (Solberg et al., 2008), the allele frequency of HLA-DRB1*04:01 is around 0.03 in Spain, around 0.1 in Caucasians in the USA, but around 0.02 in other ethnicities in the USA, around 0.01 in China, and 0.008 in Canada.
