Table 4.

Associations between guideline adherence and ESKD risk using time-dependent Cox models

	ADA guideline		Chinese guideline
	Adjusted HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Antihyperglycemic therapy	0.71 (0.55 to 0.9)	0.006	0.74 (0.58 to 0.95)	0.016
Hypertension control	0.89 (0.66 to 1.21)	0.471	0.66 (0.50 to 0.87)	0.004
Lipid management	0.95 (0.76 to 1.19)	0.658	0.52 (0.39 to 0.71)	<0.001

Adjusted HR and p value were obtained via time-dependent Cox models to adjust for sex, age, eGFR, duration of diabetes and time-dependent covariates (HbA1c, systolic BP, diastolic BP, LDL-C, TG, PRO, UA).

ADA, American Diabetes Association; BP, blood pressure; eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease; HbA1c, hemoglobin A1c; LDL-C, low-density lipoprotein cholesterol; PRO, proteinuria; TG, triglyceride; UA, uric acid.