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. 2020 Jul 16;8(2):e000351. doi: 10.1136/jitc-2019-000351

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Systemic IFN-γ was significantly induced by the RT/αPD-1 double therapy, but not the RT/αPD-1/IDO1i triple therapy. The blood serum collected from KPC orthotopic implantation model treated with combinational therapy was analyzed by Luminex cytokine profile. (A) IFN-γ, (B) IL-22, (C) IL-5, (D) sCD40L. Data represent mean±SEM of four mice per treatment group that was repeated twice. *P<0.05; NS, not significant, by unpaired t-est and one-way ANOVA. ANOVA, analysis of variance; IDO1, indoleamine 2,3-dioxygenase 1; IFN-γ, interferon-γ; IL-22, interleukin-22; RT, radiation therapy.