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. Author manuscript; available in PMC: 2020 Jul 18.
Published in final edited form as: ACS Chem Neurosci. 2018 Feb 13;9(5):1166–1183. doi: 10.1021/acschemneuro.8b00010

Table 2.

Comparison of Natural and Semisynthetic C-Glycosylflavones on GSK-3β Inhibition and CLogP

cmpd no. GSK-3β inhibition, IC50 (μM)aj CLogPb cmpd no. GSK-3β inhibition, IC50 (μM)a CLogPb
 1 184.9 ± 1.4 0.21 17 9.0 ± 1.3 2.55
 2 194.1 ± 1.0 0.80 18 26.0 ± 1.2 3.16
 3 5153 ± 31 0.21 19 33.5 ± 0.8 3.17
 4 3.1 ± 1.3 2.31 20 19.7 ± 1.1 2.21
 5 239.2 ± 1.2 1.28 21 15.8 ± 1.2 2.34
 6 237.3 ± 1.4 0.80 22 35.6 ± 1.3 1.54
 7 135.0 ± 1.3 1.21 23 35.1 ± 1.0 1.45
 8 29.2 ± 1.1 1.57 24 56.2 ± 1.2 2.61
 9 5.4 ± 0.1 1.35 25 21.7 ± 1.2 2.48
 10 33.3 ± 1.1 2.10 26 34.8 ± 1.0 0.77
 11 31.1 ± 1.2 1.97 27 19.3 ± 0.8 1.31
 12 28.0 ± 1.1 2.63 28 49.5 ± 1.2 1.00
 13 9.4 ± 0.9 3.16 29 17.2 ± 0.9 1.29
 14 25.8 ± 1.1 1.10 30 0.59 ± 0.04 1.62
 15 61.9 ± 1.2 1.43 31 2.3 ± 0.5 1.62
 16 13.1 ± 1.1 1.99
a

IC50 values were the mean of quadruplicate of each of two independent experiments.

b

CLogP values were calculated by a fragment-based method.34

cmpd, compound.