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. Author manuscript; available in PMC: 2020 Jul 18.
Published in final edited form as: ACS Chem Neurosci. 2018 Feb 13;9(5):1166–1183. doi: 10.1021/acschemneuro.8b00010

Table 3.

PAMPA Permeability and CLogP Values of Compounds Tested

PAMPA permeability
cmpd no. Pe (×10−6 cm/s)a R (%)b permeability classificationc CLogP
isoorientin (1) 0.51 ± 0.01 48 low 0.21
luteolin (4) 1.42 ± 0.07 43 medium 2.31
9 1.55 ± 0.06 46 high 1.35
17 1.77 ± 0.07 20 high 2.55
21 1.35 ± 0.08 30 medium 2.34
30 2.23 ± 0.21 30 high 1.62
theophylline 0.04 ± 0.01 n/a low −0.03
atenolold 0.29 ± 0.09 40 low −0.11
desipramined 13.43 ± 0.91 96 high 4.47
a

Pe values were the mean of PAMPA measurements (n = 3–4) with ± SD.

b

Percent recovery (R%) measures mass retention of compounds trapped inside the PAMPA membrane.

c

PAMPA permeability classification: high (Pe > 1.5 × 10−6 cm/s), medium (1.0 × 10−6cm/s ≤ Pe ≤ 1.5 × 10−6 cm/s), low (Pe < 1.0 × 10−6 cm/s).

d

The measured Pe values are comparable to the data in ref 36.