Table 3.

Treatment-related changes in subcortical volume.

	ESC/MEM Median GMV change (min, max)	ESC/PBO Median GMV change (min, max)	Kruskal- Wallis test statistic (p- value)
Subcortical volumes
Left hemisphere
Hippocampus	−8.8 (−182.4, 21.6)	−32.7 (−143.8, 18.9)	.17 (p=.68)
Thalamus	−13.6 (−247.6, 186.3)	−3.7 (−285.9, 146.7)	.13 (p=.72)
Caudate	0.3 (−122.9, 202.5)	19.9 (−180.7, 253.4)	<.01 (p=.96)
Putamen	12.3 (−42.7, 112.2)	1.2 (−108.3, 132.3)	.79 (p=.38)
Pallidum	−0.8 (−111.0, 69.5)	−3.3 (−133.0, 109.1)	.16 (p=.69)
Cerebellum	−646.6 (−2,175.5, 884.1)	−102.2 (−1,193.0, 982.5)	1.82 (p=.19)
Right hemisphere
Hippocampus	−35.8 (−163.7, 103.7)	−26.1 (−225.9, 29.3)	.14 (p=.72)
Thalamus	−33.3 (−375.6, 88.3)	−35.4 (−235.1, 91.3)	.01 (p=.92)
Caudate	−8.7 (−93.4, 119.5)	−61.2 (−301.3, 150.7)	1.41 (p=.25)
Putamen	−17.2 (−124.3, 117.3)	−38.3 (−215.4, 124.8)	1.63 (p=.22)
Pallidum	2.4 (−76.6, 73.1)	−21.6 (−88.1, 95.2)	.06 (p=.82)
Cerebellum	−360.5 (−2,644.6, 934.2)	−351.5 (−1,179.3, 978.9)	.77 (p=.39)