Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 14;13:6873–6884. doi: 10.2147/OTT.S256153

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Zhu et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

miR-27a-3p directly targeted BTG2 and regulated its expression in BC cells. (A) A negative correlation was seen between the expression levels of miR-27a-3p and BTG2 in BC specimens from TCGA (r = −0.288; P < 0.05). (B) The seed sequence of miR-27a-3p is complementary to the 3ʹUTR of BTG2. (C) Luciferase activity was analyzed in MCF-7 cells transfected with miR-27a-3p mimics and miR-NC. (D) Western blot analysis demonstrated levels of BTG2 protein in MCF-7 and MCF-7/ADR cells transfected with miR-27a-3p mimics or inhibitors. (E) qRT-PCR was performed to examine the relative expression of BTG2 mRNA in MCF-7 and MCF-7/ADR cells transfected with miR-27a-3p mimics or inhibitors. **P < 0.01; ***P < 0.001. The data are expressed as mean ± SD.