Table 2.

Outcomes for earlier vs. later refeeding after necrotizing enterocolitis without Bell’s Stage I NEC infants.

	Bohnhorst et al. (2003) [14]		Brotschi et al. (2009) [15]		Arbra et al. (2018) [12]		All three studies combined
	Earlier (median 4 d) n = 26	Later (median 10 d) n = 18	Earlier (<5 d) n = 30	Later (>5 d) n = 17	Earlier (<7 d) n = 23	Later (n≥7 d) n = 84	Earlier (median 4 d, <5–7 d) n = 79	Later (median 10 d, ≥5–7 d) n = 119
Recurrent NEC	2 (8%)	1 (6%)	1 (3%)	2 (12%)	0 (0%)	11 (13%)	3 (4%)	14 (12%)
Post-NEC stricture	2 (8%)	2 (11%)	1 (3%)	4 (24%)	0 (0%)	2 (2%)	3 (4%)	8 (7%)
Composite outcome (Recurrent or Stricture)	4 (15%)	3 (17%)	2 (7%)	6 (35%)	0 (0%)	13 (16%)	6 (8%)	22 (19%)
CLABSI after NEC	18%	29%	0 (0%)	5 (29%)	1 (4%)	8 (10%)	6 (8%)	19 (16%)
Time to full feeds after NEC	10 (7–31 d)	19 (9–76 d)	14.9 ± 4 d	18.5 ± 5.9 d	9.9 ± 4.8 d	11.0 ± 9.6 d	11.6 ± 2.9 d	16.2 ± 4.5 d

Categorical data shown as count (percentage or percentage alone). Continuous data shown as median (range) or mean ± standard deviation. d days.