eTable 1.

Empirical Dose Adjustment Schedule after Gaps in SCIT Administration Based on Mean Replies From the AAAAI Members' Survey (Aqueous Extracts)

All patients Intuitively, highly sensitive patientsa might need special caution and more drastic dose reduction after gaps
Dose increase phase	Dose adjustment actions to be taken
<2 wk since the last dose	Increase normally
≥2-3 wk	Repeat the last dose
≥3-4 wk	Reduce 1 dose
≥4-5 wk	Reduce 2 doses
90 d	Restart SCIT: from bottle 1, first dose
Maintenance phase
<5 wk since the last dose	Apply normally
≥5-7 wk	Reduce by 25%
≥7-11 wk	Reduce 1 dose/Reduce by 45%
≥8-15 wk	Reduce 2 doses/Reduce by 55%
≥3-4 mo	Restart SCIT: from bottle 1, first dose

Abbreviations: AAAAI, American Academy of Allergy, Asthma, and Immunology; SCIT, subcutaneous allergen immunotherapy.

^aSpecial caution might be needed for the following: (1) history of anaphylaxis or mast cell disorder; (2) moderate to severe asthma; (3) high sensitization pattern or systemic reaction during skin prick testing; (4) systemic reactions to previous SCIT administration; (5) patients receiving SCIT during peak pollen season for an allergen to which they are highly sensitized; and (6) pediatric patients.