eTable 4.

Dose Adjustment Schedule for Gaps in SCIT Administration, University of Cincinnati

For lapses in therapy in the 1:10,000, 1:1000, and 1:100 vials, adjust the dose as follows:
Weeks overdue
1 wk overdue	Repeat the last dose
2 wk overdue	Decrease by 1 dose
3 wk overdue	Decrease by 2 doses
4 wk overdue	Ask MD
For lapses in therapy in the 1:10 vial, adjust the dose as follows:
Wk overdue
2 wk overdue	Reduce by 50%
3 wk overdue	Start at the beginning of vial
4 wk overdue	Ask MD
For lapses in therapy in the 1:1 vial, adjust the dose as follows:
Weeks overdue
1-2 wk overdue	Repeat the last dose
3-4 wk overdue	Decrease by 1 dose
4-6 wk overdue	Decrease by 2 doses
>6 wk overdue	Ask MD

Abbreviation: MD, doctor of medicine.

NOTE: Normal dosing of vials 1:10,000 and 1:1000 is with 0.10 mL increments, 1:100 and 1:10 with 0.05 increments, and 1:1 with 0.03 increments.