eTable 6.
Practice Parameters (Third Update) of Online Repository Proposed Schedule (eTable 5)
| Build-up phase for weekly or biweekly injections | |
| Modify dosage accordingly to time interval since missed injection | |
| Up to 7 da | Continue as scheduled |
| 8-13 d after missed scheduled injection | Repeat the previous doseb |
| 14-21 d after missed scheduled injection | Reduce the dose by 25%b |
| 21-28 d after missed scheduled injection | Reduce the previous dose by 50%b |
| A similar dose reduction protocol should be developed for gaps in maintenance immunotherapy. | |
a
If on weekly build-up, then it would be up to 14 days after administered injection or 7 days after the missed scheduled injection.
b
Then increase dose each injection visit as directed on the immunotherapy schedule until the therapeutic maintenance dose is reached.