Table 3.
Univariable and multivariable Cox proportional hazards regression analysis on the association between sociodemographic and clinical characteristics and mortality of the overall cohort
| Univariable HR (95% CI) | Multivariable1 HR (95% CI) – Overall | |
|---|---|---|
| Tumor type | ||
| GCTs | Ref. | Ref. |
| SCSTs | 2.96 (2.03–4.33)*** | 1.68 (1.13–2.49)* |
| Age (per 5-year increase) | 1.21 (1.19–1.23)*** | 1.18 (1.16–1.20)*** |
| Race/ethnicity | ||
| Non-Hispanic White | Ref. | Ref. |
| Non-Hispanic Black | 1.80 (1.41–2.29)*** | 1.13 (0.89–1.45) |
| Hispanic/other | 1.27 (1.13–1.43)*** | 1.14 (1.01–1.30)* |
| Insurance | ||
| Private insurance | Ref. | Ref. |
| Uninsured | 2.63 (2.29–3.01)*** | 2.31 (2.01–2.66)*** |
| Medicaid/Medicare/other government insurance | 4.33 (3.88–4.83)*** | 2.72 (2.42–3.05)*** |
| Income (per year) | ||
| < $38,000 | Ref. | Ref. |
| $38,000–$62,999 | 0.71 (0.62–0.81)*** | 0.94 (0.82–1.09) |
| > $63,000 | 0.44 (0.38–0.50)*** | 0.76 (0.63–0.92)** |
| Percent in ZIP code without a high school diploma | ||
| > 21% | Ref. | Ref. |
| 7–20.9% | 0.63 (0.56–0.71)*** | 0.83 (0.73–0.96)* |
| < 7% | 0.43 (0.37–0.49)*** | 0.74 (0.61–0.90)** |
| Residence | ||
| Metropolitan | Ref. | Ref. |
| Urban/rural | 1.49 (1.33–1.67)*** | 1.13 (1.00–1.29) |
| Charlson-Deyo comorbidity score | ||
| 0 | Ref. | Ref. |
| > 1 | 3.23 (2.82–3.70)*** | 2.06 (1.79–2.37)*** |
CI = Confidence interval, GCTs = Germ cell tumors, HR = Hazard ratio, SCSTs = Sex cord stromal tumors
*p < 0.05
**p < 0.01
***p < 0.001
1The following variables were included in the multivariable analysis: tumor type, age, diagnosis year, race/ethnicity, insurance, yearly income, percent in ZIP code without a high school diploma, residence, Charlson-Deyo comorbidity score