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HER2 classification changes in the NAT and no-NAT group from paired biopsy and surgical specimens
| Surgery Biopsy |
Negative | Ambiguous | Positive | p value | No. cases with loss of HER2 | No. cases with gain of HER2 | |
|---|---|---|---|---|---|---|---|
| No-NAT group (N = 61) | Negative | 40 | 5 | 2 | 0.4165 | 2 | 8 |
| Ambiguous | 1 | 3 | 1 | ||||
| Positive | 0 | 1 | 8 | ||||
| NAT group (N = 78) | Negative | 55 | 4 | 1 | 0.6616 | 4 | 5 |
| Ambiguous | 2 | 5 | 0 | ||||
| Positive | 2 | 0 | 8 | ||||
| Unkown | 0 | 1 | 0 |
NAT Neoadjuvant therapy
