Table 6.

the function index at week 4, 8, 12

Secondary outcomes	Overall effect						Heterogeneity test			Figure	Reference
	MD	95%CI	P	Tau2	I2 (%)	P	Statistical method	Studies (N)	Sample size (N)
WOMAC pain at 4 weeks	− 7.18	− 10.56, − 3.80	<0.0001	9.23	81	0.0003	Random inverse variance	3	186	Fig S10	[24, 26, 33]
WOMAC pain at 8 weeks	− 8.95	−13.56, − 4.35	0.0001	14.91	84	0.0004	Random inverse variance	2	127	Fig S11	[24, 26]
WOMAC pain at 12 weeks	− 12.79	−18.41, − 7.43	<0.00001	22.56	94	<0.00001	Random inverse variance	3	262	Fig S12	[24, 26]