Fig. 1.

Generation of T2D mice by high-fat diet feeding and STZ injection. a Image of representative T2D and C57BL/6 control mice at 19 weeks of age. b Body weights and c fed blood glucose levels of T2D mice and Chow diet mice (Chow). d Blood glucose levels of Chow and T2D mice during an IPGTT. e Area under the curve of IPGTT. f Blood glucose levels during the ITT of T2D mice and C57BL/6 mice. g Area under the curve during the ITT. C57BL/6 group, n = 24, T2D group, n = 46. *P < 0.05; **P < 0.01, ANOVA test. T2D mice: fed high-fat diet and received STZ injection; C57BL/6: mice fed standard diet