Table 2.
Major histone deacetyltransferase families
| Class of HDAC | members of each class | homology to yeast | location | HDACs as anticancer targets |
|---|---|---|---|---|
| class I | HDACS 1, 2, 3 and 8 | RPD3 protein | in the nucleus |
i) DNA-based process (DNA repair, replication and recombination) ; ii) cell-cycle progression (cell proliferation, differentiation, apoptosis) ; iii) migration; iiii) immunity. (See below for more details) |
| class IIa | HDACs 4, 5, 7 and 9 | Hda1 protein | shuttle between the nucleus and the cytoplasm | |
| class IIb | HDACs 6 and 10 | |||
| class IV | HDAC11 | mixed homology between Rpd-3 and Hda1 | in the nucleus | |
| class III | (NAD+-dependent) SIRT1, 2, 3, 4, 5, 6 and 7 | Sir2 protein | in the nucleus |