Table 5.
Mechanisms of HDACis in GBM
| alterations | affected part | agents |
|---|---|---|
| p21Waf1/Cip1, p27↑ | cell cycle arrest | SAHA [151], I-BET151 [164], TSA [165], NaB [166], PB [167], FK228 [168], DATS [169], PXD-101 [170], NBM-HD-3 [171], Scriptaid [172], MS-275 [173] |
| DR5, TNFα, p53, Bad, Bax, Bim, chop, Puma, m-calpian↑ | proapoptotic genes | SAHA [151], TSA [166], NaB [166], VPA [174], FK228 [152], DATS [169], PXD-101 [170], DWP0016 [175] |
| vasculogenic mimicry, VEGF, EGFR↓ | angiogenesis | SAHA , MS-275, MC1568, TSA [176], NaB [177], DATS [169], LBH589 [178] |
| Bcl2, Bcl-XL↓ | antiapoptotic genes | VPA [174], PB [167], FK228 [168], DATS [169] |
| EZH2, MMP-2↓ | invasion | SAHA [179], VPA [174], FK228 [168], W2 [180] |
| p-PTEN/p-AKT, pFAK/p-STAT3↓ | pathways | TSA [181], DATS [169], NBM-HD-3 [171], W2 [180] |
| CDK2, CDK4, CDK6, cyclins D1, cyclins D2↓ | progrowth genes | SAHA [151], TSA [165] |
| caspase 8, caspase 9, caspase 3 | apoptotic cascade activation | SAHA [182], DATS [169] |
| HOTAIR↓ | tumor promoting lncRNA | I-BET151 [183] |
| Ras, c-myc↓ | oncogenes | Scriptaid [172], DATS [169] |
| CD133, Bmi1↓ | GSCs markers | SAHA [182] |
‘↑’ or ‘↓’, represent the up-regulated or down-regulated trend of gene expression, respectively.