Table 3.
Factors associated with good clinical outcome in patients with intracranial atherosclerotic stenosis (ICAS)-related occlusion
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Poor outcome (N = 66) |
Good outcome (N = 45) |
P | Odds ratio (95% CI) | P | |
| Demographics | |||||
| Age, years | 68.7 ± 11.9 | 60.2 ± 14.2 | 0.001 | 0.956 (0.915–0.995) | 0.035 |
| Sex, men | 39 (59.1) | 31 (68.9) | 0.395 | 0.863 (0.287–2.542) | 0.789 |
| Risk factors | |||||
| Hypertension | 46 (69.7) | 25 (55.6) | 0.186 | ||
| Diabetes mellitus | 20 (30.3) | 14 (31.1) | > 0.999 | ||
| Dyslipidemia | 22 (33.3) | 13 (28.9) | 0.774 | ||
| Atrial fibrillation | 12 (18.2) | 12 (26.7) | 0.406 | ||
| Smoker | 20 (30.3) | 19 (42.2) | 0.276 | ||
| Initial occlusion site | 0.001 | ||||
| Internal carotid artery | 13 (19.7) | 1 (2.2) | Ref | ||
| Middle cerebral artery | 36 (54.5) | 39 (86.7) | 12.544 (1.777–259.986) | 0.030 | |
| Vertebral/Basilar artery | 17 (25.8) | 5 (11.1) | 5.021 (0.520–117.656) | 0.206 | |
| Initial NIHSS score | 19 (14–23) | 12 (9–16) | < 0.001 | 0.830 (0.742–0.913) | < 0.001 |
| ASPECTS scorea | 7 (4–8) | 8 (6–10) | 0.005 | ||
| Onset to door time, min | 196 (120–421) | 204 (82–457) | 0.833 | ||
| Door to puncture time, min | 106 (81–130) | 107 (89–123) | 0.881 | ||
| IV tPA | 30 (45.5) | 20 (44.4) | > 0.999 | ||
| Stent retriever as first-line device | 27 (40.9) | 22 (48.9) | 0.524 | 0.987 (0.346–2.770) | 0.980 |
| Primary successful reperfusion | 35 (53.0) | 30 (66.7) | 0.217 | ||
| Final successful reperfusion | 51 (77.3) | 40 (88.9) | 0.190 | 5.479 (1.441–24.841) | 0.018 |
| Number of techniques | 2 (2–3) | 2 (1–3) | 0.457 | 1.208 (0.643–2.293) | 0.555 |
| Laboratory findings | |||||
| Hemoglobin, g/dL | 14.0 ± 1.9 | 14.0 ± 2.0 | 0.917 | ||
| White blood cells, ×109/L | 11.2 ± 5.0 | 9.4 ± 3.8 | 0.036 | 0.910 (0.784–1.039) | 0.186 |
| Platelets, ×109/L | 242 ± 72 | 236 ± 65 | 0.616 | ||
| Glucose, mmol/L | 8.2 ± 3.1 | 8.4 ± 3.5 | 0.709 | ||
aBaseline ASPECTS on quality imaging was evaluated in 81 patients (91.0% patients with anterior circulation infarction)
NIHSS National Institutes of Health Stroke Scale; ASPECTS Alberta Stroke Program Early CT Score; IV tPA Intravenous tissue plasminogen activator