Table 3.
PNPLA3 genotype CC vs. CG/GG of hereditary hemochromatosis (HH) group. Mean ± SD or median (IQR) or frequencies n (%) are shown with p-values for the group differences based on Welch’s t-test (a), Mann-Whitney U test (b) or chi-square test (c)
| limits of normal | CC n = 26 | CG/GG n = 28 | p-value | |
|---|---|---|---|---|
| Cholesterol | mg/dl | 181.6 ± 35.2 | 193.9 ± 40.8 | 0.26a |
| HDL | > 40 mg/dl | 58.8 ± 20.4 | 51.1 ± 18.1 | 0.18a |
| LDL | < 160 mg/dl | 105.8 ± 22.7 | 116.3 ± 29.3 | 0.20a |
| Triglycerides | < 150 mg/dl | 97.0 (58.8) | 128.5 (125.0) | 0.17b |
| Ferritin | μg/l | 153.5 (465.5) | 562.0 (1064.5) | 0.18b |
| Transferrin | 2.0–3.6 g/l | 1.9 ± 0.3 | 1.8 ± 0.3 | 0.40a |
| TS | 16–45% | 73.8 ± 22.8 | 68.4 ± 26.7 | 0.44a |
| Iron | 14–32 μmol/l | 33.1 ± 9.2 | 30.6 ± 11.1 | 0.34a |
| Albumin | 30–50 g/l | 44.7 ± 2.7 | 44.9 ± 2.6 | 0.79a |
| Bilirubin | < 1.0 mg/dl | 0.6 (0.5) | 0.8 (0.7) | 0.20b |
| GGT | < 60 U/l | 23.0 (39.5) | 26.0 (25.3) | 0.94b |
| AST | < 46 U/l | 25.0 (15.0) | 35.5 (20.3) | 0.04b |
| ALT | < 50 U/l | 23.5 (10.5) | 31.5 (16.5) | 0.19b |
| BMI | kg/m2 | 26.4 ± 3.9 | 25.7 ± 2.7 | 0.44a |
| FibroScan | < 6 kPa | 6.8 ± 5.4 | 6.5 ± 4.1 | 0.79a |
| Hepatic steatosis | none | 9 (34.6%) | 7 (25%) | 0.62c |
| mild | 9 (34.6%) | 9 (32.1%) | ||
| moderate | 4 (15.4%) | 8 (28.6%) | ||
| severe | 3 (3.8%) | 2 (7.1%) |
ALT alanine aminotransferase; AST aspartate aminotransferase; BMI body mass index; HDL high-density lipoprotein; IQR interquartile range; LDL low-density lipoprotein; PNPLA3. human patatin like phospholipase domain-containing 3; SD standard deviation; TS transferrin saturation;