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. 2020 Jul 18;20:674. doi: 10.1186/s12885-020-07159-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Interaction among m6A RNA methylation regulators and functional annotation of uveal melanoma in C1/2 subtypes. a The m6A modification-related interactions among the 13 m6A RNA methylation regulators. b Principal component analysis of the total RNA expression profile in the TCGA dataset. c Spearman correlation analysis of the 13 m6A modification regulators. * P < 0.05, ** P < 0.01. d The top 5 biology process (BP) terms were actively enriched in C1 expression phenotype. X-axis means the number of genes enriched in pathways, Y-axis means BP pathways. f Cancer hallmark pathways revealed that 9 malignant hallmark pathways were significantly associated with the C1 subgroup expression phenotype. X-axis means the number of genes enriched in pathways, Y-axis means hallmark pathways