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. 2020 Jul 17;17:214. doi: 10.1186/s12974-020-01888-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Immunohistochemical analysis of microglial cells and astrocytes in the brains of ⍺-synuclein transgenic mice. a Representative bright field light microscopy images from the neocortex, hippocampus, striatum, and thalamus of non-tg and ⍺-syn tg mice immunostained with an antibody against Iba1 (microglial cell marker). b Computer-based image analysis showing increased numbers of Iba1 positive cell in the neocortex, hippocampus, and striatum of non-tg and ⍺-syn tg mice. c Representative bright field light microscopy images from the neocortex, hippocampus, striatum, and thalamus of non-tg and ⍺-syn tg mice immunostained with an antibody against GFAP (astroglial cell marker). d Computer-based image analysis showing increased numbers of GFAP positive cells in the neocortex, hippocampus, and striatum of non-tg and ⍺-syn tg mice. Scale bars = 40 μm (low magnification) and 10 μm (high magnification). Non-tg and α-syn tg mice (n = 4). Statistical significance determined by unpaired t test; *p ≤ 0.05