Fig. 2.

Gene expression of NF-κB-activating receptors in the post-mortem dorsolateral prefrontal cortex of controls (CON) and people with schizophrenia (SCZ). Diagnostic groups were stratified based on neuroinflammatory biotype at time of death (low neuroinflammation or high neuroinflammation). High neuroinflammation groups had higher expression of all receptors in both diagnoses, with the exception of TLR4 mRNA which did not differ between high neuroinflammation and low neuroinflammation in schizophrenia, and was decreased in patients with inflammation compared to non-schizophrenic controls with neuroinflammation. Diagnostically, TNFR mRNA was upregulated in schizophrenia compared to controls (p = 0.046). Error bars depict standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns = not significant