Table 2.
SNPs Most Associated with AKI-SP2
| SNP | Associated Gene | Chromosome: Coordinate | Function | Minor Allele Frequency (1000 Genomes) |
Odds Ratio (95% CI)a |
P-value | FDR Corrected P-value |
|---|---|---|---|---|---|---|---|
| 1. rs2920656 | MCPH1 | Chr8:6329510 | Intron | 0.284 | 0.45 (0.31–0.66) | 1.38 × 10−5 | 0.0026 |
| 2. rs2442473 | ANGPT2 MCPH1 | Chr8:6358293 | Intron | 0.082 | 0.40 (0.22–0.74) | 0.001902 | 0.0723 |
| 3. rs2920689 | MCPH1 | Chr8:6343499 | Intron | 0.310 | 0.59 (0.42–0.82) | 0.001538 | 0.0731 |
| 4. rs2959779 | MCPH1 | Chr8:6443380 | Intron | 0.055 | 0.27 (0.11–0.67) | 0.001307 | 0.0828 |
| 5. rs2440399 | MCPH1 | Chr8:6325975 | Intron | 0.207 | 0.52 (0.34–0.78) | 0.000984 | 0.0935 |
Definition of abbreviations: SNP single nucleotide polymorphism, CI confidence interval, FDR False Discovery Rate
aAdditive genetic model adjusted for age, gender, sepsis and 5 principal components