Table 3.

ANG-2 Renal Clearance in Subjects with and without AKI

Timed Urine Collection	Average Serum Creatinine (mg/dL)	Average Plasma ANG-2 (pg/mL)	Urine ANG2 (pg/mL)	ANG-2 Renal Clearance (mL/min)
1	3.24	29,312.89	4671.87	0.216
2	3.52	27,136.51	5915.63	0.353
3	0.82	5061.54	10.00	0.002
4	0.89	4782.57	553.81	0.161
5	0.61	4435.69	169.09	0.064
6	0.53	3867.01	10.00	0.006
7	0.75	10,426.38	11.80	0.004
8	0.69	9699.06	14.58	0.002
9	0.60	6593.72	10.00	0.004
10	0.82	8350.90	190.68	0.010
11	0.71	15,886.06	220.09	0.003
12	0.69	10,096.66	243.74	0.018
13	2.57	26,288.02	2097.31	0.079
14	2.24	24,769.31	1967.59	0.165
15	2.16	22,259.65	1696.53	0.074
16	0.99	10,839.17	10.00	0.002
17	0.44	2624.28	10.00	0.007
18	1.20	18,067.95	192.79	0.014
19	1.14	13,683.26	527.93	0.069
20	1.13	8829.19	245.35	0.095

Serum creatinine and plasma ANG-2 calculated based on the average measurement from the plasma sample collected at the beginning and at the end of the time urine collection. Clearance calculated using the formula Clearance (X) = U(X) * V/ P(X), where U(X) represents the urine concentration of solute X, V indicates the urine volume over the 2–4-h collection period, and P (X) represents the average plasma concentrations of solute X from the initial and final blood collection