Fig. 3.

Model comparison to validation data. a Relative change of pAkt upon stimulation with 10 ng/ml (0.43 nM) FGF compared with reference time point (30 min). b Relative change of Akt phosphorylation upon stimulation with 20 ng/ml (0.44 nM) VEGF compared with reference time point (45 min). c Relative change of VEGFR2 phosphorylation upon stimulation with 80 ng/ml (1.78 nM) VEGF using the reference time point of 7 min. Circles are experimental data from HUVECs. Curves are the mean model predictions of the 15 best fits from the model training. Shaded regions show standard deviation of the fits