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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Cell Chem Biol. 2020 May 14;27(7):866–876.e8. doi: 10.1016/j.chembiol.2020.04.008

Figure 5. Lenalidomide Analogues Did Not Induce Degradation of Selected CRBN Neo-substrates.

Figure 5.

(A)-(E) MM1S cells were treated with CRBN ligands or vehicle (6 h) and analyzed by in-cell ELISA or Western blot. For anti-proliferation results and additional blots, see Figure S3 and S4. Bar graphs were generated as means of protein (IKZF1 or IKZF3) relative expression (n = 3) with ± SD as the error bar. Variances were analyzed by one-way ANOVA and multiple group comparison with corresponding “vehicle only” group were followed Dunnett correction. Not significant (ns) P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. “ns” was obtained for any bar without asterisk rating.