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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Cell Chem Biol. 2020 May 7;27(7):780–792.e5. doi: 10.1016/j.chembiol.2020.04.006

Figure 5. E1 sequences of (S)-CCZ cross-linking site and mutational analyses.

Figure 5.

A. E1 Sequence comparison of various HCV genotypes near the major amino acid residues cross-linked with CCZ (marked by *) was shown as in Figure 1. B. Dose-response curves of (S)-CCZ against the HCV GT2a WT and mutants W214Y, Q215E and W214Y/Q215E. The experiment was performed in 96-well plates. Data points are expressed as mean values ± SEM from 6 samples (n = 6). The results are representative of three separate experiments.