Table 2.
Median ACE2 and TMPRSS2 TPM Expression Values.
| TMPRSS2 | Male median TPM | Female median TPM | P value |
|---|---|---|---|
| Stomach | 109.4 | 132.5 | 0.309 |
| Colon-transverse | 104.1 | 90.8 | 0.460 |
| Small intestine | 63.6 | 86.1 | 0.186 |
| Lung | 48.2 | 49.5 | 0.244 |
| Pancreas | 52.7 | 51.0 | 0.436 |
| Salivary gland | 46.3 | 42.5 | 0.228 |
| Esophagus | 32.7 | 28.8 | 0.649 |
| Kidney | 31.6 | 31.1 | 0.876 |
| Thyroid | 21.6 | 21.1 | 0.921 |
| Liver | 12.2 | 14.6 | 0.284 |
| ACE2 | Male median TPM | Female median TPM | P value |
|---|---|---|---|
| Small intestine | 38.0 | 50.7 | 0.385 |
| Adipose tissue subcutaneous | 1.3 | 2.2 | <0.0001 |
| Adipose tissue visceral | 5.5 | 5.4 | 0.971 |
| Thyroid gland | 4.4 | 3.4 | 0.059 |
| Kidney | 4.7 | 8.8 | 0.104 |
| Heart atrial appendage | 3.6 | 3.4 | 0.563 |
| Heart left ventricle | 4.7 | 5.7 | 0.104 |
| Colon-sigmoid | 0.2 | 0.2 | 0.769 |
| Colon-transverse | 3.3 | 4.0 | 0.460 |
| Lung | 0.7 | 0.6 | 0.574 |
| Salivary gland | 1.5 | 1.6 | 0.636 |
The data were obtained from The Human Protein Atlas GTEx data (RNAseq based on RSEMv1.2.22 [v7]) and sorted from the highest expressing tissues from male and female patients (all age groups included). Box plots were created using SPSS Software (IBM, Chicago, Illinois), and extreme outliers in each type of sample were identified. If extreme outliers were present in the sample population, the significance of the difference was calculated using the Mood’s median test. For all other samples without extreme outliers, Kruskal–Wallis was used to calculate the significance.
TPM = transcripts per million.