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. 2020 Jul 19;164:616–625. doi: 10.1016/j.ijbiomac.2020.07.178

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© 2020 Published by Elsevier B.V.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Schematic representation of the mechanisms of action of sPLA₂s from snake venom on viral replicative cycle. sPLA₂s, which possess antiviral activity, are indicated in early and/or late stages of the viral life cycle: entry, replication and release. Mt-I and Mt-II (Bothrops asper), BthTX-I (Bothrops jararacussu), crotoxin, PLA₂-CB and PLA₂-IC (Crotalus durissus terrificus), CM-II-sPLA₂ and Nmm_CMIII (Naja mossambica mossambica), nigexine (Naja nigricollis), taipoxin (Oxyuranus scutellatus), BlK-PLA₂ and BlD-PLA₂ (Bothrops leucurus) are demonstrated.