Fig. 2.

Docking simulations between sPLA₂s and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC). Mt-I (A) and Mt-II (B) are showed as surface and the enzymatic site is colored. The amino acids from the enzymatic site are H48 in red, D49 (Mt-I) or K49 (Mt-II) in blue, and Y52 in green. The POPC is showed as wire structure. The aspartic acid has a smaller volume than lysine, which may result in a less open entrance in Mt-II (panel B) compared with Mt-I (panel A). H: histidine; D: aspartate; K: lysine; Y: tyrosine. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)