FIGURE 10.

mTOR regulates BMP signaling in differentiation OPCs. Schematic illustrating mTOR regulation of BMP signaling in spinal cord OPCs. In control OPCs, mTOR either directly or indirectly inhibits BMPs and BMPR1. mTOR promotes FKBP12 expression and formation of the regulatory complex at the Id2 promoter. Compared to control cells, mTOR cKO OPCs have decreased expression of FKBP12, increased BMP signaling at the receptor, and increased downstream phosphorylation of Smad1/5/8. When mTOR is inhibited, the levels of Sip1 and HDAC2 bound to the Id2 promoter are reduced, resulting in increased expression of Id2, an inhibitor of oligodendrocyte differentiation