Table 2.

Univariate and multivariate analysis of prognostic factors in progression free survival

	Univariate analysis				Multivariate analysis
Variable	HR	95.0% CI		P value	HR	95.0% CI		P value
Age (y) ≤55 vs. > 55	1.351	0.903	−2.020	0.143	–	–	–	–
Postoperative residual disease Microscopic vs. Macroscopic	3.637	2.376	−5.566	P < 0.001	2.761	1.752	−4.351	P < 0.001
Grade Low vs. High	2.499	1.535	−4.067	P < 0.001	1.912	1.141	−3.202	0.014
Stage I or II vs. III or IV	2.344	1.360	−4.039	0.002	1.592	0.883	−2.872	0.122
Platelet count (1000/μl) ≤300 vs. > 300	1.820	1.214	−2.728	0.004	1.626	1.073	−2.466	0.022
Platelet count reduction > 25% vs. ≤25%	1.594	1.068	−2.378	0.023	1.651	1.100	−2.478	0.015
Plasma fibrinogen(g/l) 2–4 vs. > 4	0.914	0.592	− 1.411	0.685	–	–		–
Plasma D-dimer (mg/l) ≤0.3 vs. > 0.3	0.894	0.507	−1.574	0.697	–	–	–	–

CI confidence interval, HR hazard ratio