Fig. 2.

Target-centered miR-target molecular interaction network. This network describes interactions between miRs and the mRNAs encoding AD-relevant microglial proteins. The network was constructed in Cytoscape [73] by seeding with 40 AD-relevant microglial gene symbols (Supplementary Table 1) and importing molecular interaction data from the EBI-GOA-miR file (accessed 1 July 2019). The protein-protein interactions (PPIs) edges were added to the network manually, based on data from another network seeded with the 17 AD-relevant microglial proteins shown in this Figure 2 (Supplementary Figure 1, Supplementary Table 7). The colors of node fragments correspond to GO terms (see key). Data associated with the enriched GO terms displayed in this figure is summarized in Table 4.