Fig. 3.

MiR-centered miR-target molecular interaction sub-network constructed by selecting four miRs enriched for ‘regulation of neuroinflammatory response’ and their direct targets. The sub-network was constructed in Cytoscape [73]. BiNGO [38] results (Supplementary Figure 2 and Supplementary Table 10) were used to identify relevant nodes and the first neighbors of the selected nodes. The four hub nodes represent miRs. The hub nodes are linked to the target nodes by the dashed edges, which represent experimentally demonstrated associations between miRs and their targets shown as nodes labelled with the HGNC-approved gene symbols. The purple cap at the end of each edge faces the target of miR silencing. The BiNGO enrichment analysis had been performed on the original large network of 415 nodes, shown in Supplementary Figure 2 and Supplementary Table 9. Key BiNGO analysis results are shown Table 5; all of the analysis results are provided in Supplementary Table 10. The background colors of the nodes’ fragments correspond to GO terms shown on the same background colors in the ‘Key to background colors’ text box.