Table 5.

Selection of GO terms enriched in the Cytoscape BiNGO analysis of the miR-centered molecular interaction network. The network, shown in Supplementary Figure 2, was constructed in Cytoscape [73] by seeding with the 66 miRs prioritized for annotation (Supplementary Table 2) and importing molecular interaction data from the EBI-GOA-miRNA file [52] (accessed 19 August 2019). All results of the BiNGO enrichment analysis are provided in Supplementary Table 10

Gene Ontology term	n (N = 52563)	x (X = 410)	Expected	Fold enrichment	p
neuroinflammatory response	48	14	0.37	37.39	1.12E-17
regulation of neuroinflammatory response	44	13	0.34	37.88	1.53E-16
inflammatory response	570	49	4.45	11.02	4.09E-34
regulation of inflammatory response	407	60	3.17	18.90	7.87E-56
microglial cell activation	37	10	0.29	34.65	1.81E-12
regulation of microglial cell activation	21	6	0.16	36.63	5.81E-08
cytokine-mediated signaling pathway	53	6	0.41	14.51	1.40E-05
regulation of cytokine-mediated signaling pathway	181	28	1.41	19.83	1.48E-26
regulation of cytokine production	793	84	6.19	13.58	7.80E-67

Key: Gene Ontology (GO) term name; n, number of entities associated with a given GO ID in the whole reference set of 52563 human entities annotated with GO (N); x, number of entities associated with a given GO ID in the analyzed network of a total number of 410 entities (X); Expected, the number of genes in the query dataset expected to be associated with a given GO term by chance; Fold Enrichment, the ratio of the obtained versus expected number of genes associated with a given GO term in the analyzed group of genes; p-value, corrected p-value obtained using the Benjamini & Hochberg False Discovery Rate (FDR) correction (significance level chosen as 0.05).