Table 5.
Gene Ontology term | n (N = 52563) | x (X = 410) | Expected | Fold enrichment | p |
neuroinflammatory response | 48 | 14 | 0.37 | 37.39 | 1.12E-17 |
regulation of neuroinflammatory response | 44 | 13 | 0.34 | 37.88 | 1.53E-16 |
inflammatory response | 570 | 49 | 4.45 | 11.02 | 4.09E-34 |
regulation of inflammatory response | 407 | 60 | 3.17 | 18.90 | 7.87E-56 |
microglial cell activation | 37 | 10 | 0.29 | 34.65 | 1.81E-12 |
regulation of microglial cell activation | 21 | 6 | 0.16 | 36.63 | 5.81E-08 |
cytokine-mediated signaling pathway | 53 | 6 | 0.41 | 14.51 | 1.40E-05 |
regulation of cytokine-mediated signaling pathway | 181 | 28 | 1.41 | 19.83 | 1.48E-26 |
regulation of cytokine production | 793 | 84 | 6.19 | 13.58 | 7.80E-67 |
Key: Gene Ontology (GO) term name; n, number of entities associated with a given GO ID in the whole reference set of 52563 human entities annotated with GO (N); x, number of entities associated with a given GO ID in the analyzed network of a total number of 410 entities (X); Expected, the number of genes in the query dataset expected to be associated with a given GO term by chance; Fold Enrichment, the ratio of the obtained versus expected number of genes associated with a given GO term in the analyzed group of genes; p-value, corrected p-value obtained using the Benjamini & Hochberg False Discovery Rate (FDR) correction (significance level chosen as 0.05).