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. Author manuscript; available in PMC: 2020 Jul 19.
Published in final edited form as: Annu Rev Immunol. 2020 Jan 13;38:229–247. doi: 10.1146/annurev-immunol-091319-083608

Figure 3.

Figure 3

Neonatal T cells exhibit innate-like functions. This diagram shows how neonatal T cells express hardwired receptors and display functions that are more typically associated with innate and innate-like T cells. For example, naive neonatal T cells can express Toll-like receptors (TLRs), complement receptors, and natural killer (NK) cell receptors, as well as a more peptide-promiscuous T cell receptor (TCR). Following TCR stimulation, neonatal T cells also rapidly produce IL-8, which is consistent with their more broadly reactive nature. In contrast, adult T cells express a higher avidity TCR and produce more conventional cytokines (IFN-γ or IL-4 and IL-13) after clonal proliferation and differentiation.