| m, mucosa; m1, limited to the epithelium; m2, invasion of the lamina propria mucosae; m3, invasion of the muscularis mucosae; sm, submucosa; SCC, squamous cell carcinoma; AC, adenocarcinoma; ER, endoscopic resection; CRT, chemoradiotherapy; †, if ≥3/4th to complete encircling of the circumference: additional chemo(radio)therapy; ††, evaluate patient’s surgical tolerability; †††, when vascular invasion presents; ‡, absolute indication when well differentiated (G1/2), no evidence of lymph (L0) or vascular invasion (V0); ‡‡, relative indication, only in selected cases (high risk of lymph node metastases); §, absolute indication when L0−V0;§§, relative indication when G1/2, depth of invasion ≤200 μm (SCC) or 500 μm (AC), L0, V0, no ulceration (multidisciplinary discussion); §§§, further treatment after endoscopic resection when: ≥sm2/>200 μm/poorly differentiated/lymphatic invasion (L+)/vascular invasion (V+)/positive vertical margins.
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