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. 2020 Jun;32(3):271–286. doi: 10.21147/j.issn.1000-9604.2020.03.01

2. List of landmark randomized controlled trials (RCTs) on perioperative strategies in multimodal treatment of esophageal cancer.

RCTs Publication of design/results Country Status Type Therapeutic arms
SCC, squamous cell carcinoma; AC, adenocarcinoma; UK, United Kingdom; FU, fluorouracil; RT, radiotherapy; ICORG, Irish Clinical Research Group; ECF/ECX, epirubicin, cisplatin, 5-FU/capecitabine.
JCOG9204 (56) 2003 Japan Completed SCC Adjuvant chemotherapy vs. Surgery alone
MAGIC (34) 2006 UK Completed Gastric AC Perioperative 3 cycles epirubicin, cisplatin, 5-FU vs. Surgery alone
OEO2 (35) 2009 UK Completed AC+SCC Neoadjuvant 2 cycles cisplatin, 5-FU vs. Surgery alone
FNCLCC/FFCD (53) 2011 Germany Completed Esophageal + Gastric AC Neoadjuvant 2−3 cycles of cisplatin, 5-FUvs. Surgery alone
Burmeister et al. (46) 2011 Australia Completed AC Neoadjuvant cisplatin, 5-FU vs. Neoadjuvant cisplatin, 5-FU, RT
JCOG9907 (48) 2012 Japan Completed SCC Neoadjuvant cisplatin, 5-FU vs. Adjuvant cisplatin, 5-FU
JCOG1109 (49) 2013 Japan Ongoing SCC Neoadjuvant cisplatin, 5-FU vs. Neoadjuvant docetaxel vs. Neoadjuvant cisplatin, 5-FU, RT
FFCD9901 (39) 2014 Germany Completed AC+SCC Neoadjuvant 2 cycles FU, cisplatin, RT vs. Surgery alone
CROSS (37) 2015 the Netherlands Completed AC+SCC Neoadjuvant 5 cycles carboplatin, paclitaxel, RT vs. Surgery alone
Zhao et al. (60) 2015 China Completed SCC Neoadjuvant 2 cycles paclitaxel, cisplatin, 5-FU (PCF) plus adjuvant 2 cycles PCF vs. Neoadjuvant 2 cycles PCF
ESOPEC (62) 2016 Germany Ongoing AC FLOT vs. CROSS
PROTECT-1402 (64) 2016 Germany Ongoing AC+SCC Neoadjuvant paclitaxel, carboplatin, RT vs. Neoadjuvant FU, oxaliplatin, folinic acid (FOLFOX)
POET (47) 2017 Germany Closed Early AC Neoadjuvant FU, cisplatin vs. Neoadjuvant FU, cisplatin, RT
OEO5 (51) 2017 UK Completed AC Neoadjuvant 4 cycles epirubicin, cisplatin, capecitabine vs. Neoadjuvant 2 cycles cisplatin, FU
Neo-AEGIS (63) 2017 ICORG Results awaited AC MAGIC vs. CROSS
NEOCRTEC5010 (50) 2018 China Completed SCC Neoadjuvant 2 cycles vinorelbine, cisplatin, RT vs. Surgery alone
Guo et al. (61) 2018 China Ongoing SCC Adjuvant 3 cycles paclitaxel, cisplatin vs. Adjuvant RT vs. Surgery alone
FLOT4 (52) 2019 Germany Completed Esophageal + Gastric AC Neoadjuvant plus adjuvant FLO/FLOT: 5-FU, leucovorin, oxaliplatin ± docetaxel vs. Neoadjuvant plus adjuvant ECF/ECX
NeoRes (43) 2019 Scandinavia Completed AC+SCC Neoadjuvant cisplatin, 5-FU vs. cisplatin, 5-FU, RT