1. Fluzoparib pharmacokinetic (PK) parameters. (A) Plasma concentration-time profiles for fluzoparib following a single dose fluzoparib at 10 mg (n=6), 80 mg (n=10), 100 mg (n=13), 120 mg (n=8), 150 mg (n=14), 160 mg (n=3) or 200 mg (n=4) (
); (B) Plasma concentration-time profiles on d 15 for fluzoparib following multiple dose fluzoparib at 10 mg bid (n=4), 20 mg bid (n=3), 40 mg bid (n=3), 60 mg bid (n=8), 80 mg bid (n=12), 100 mg bid (n=12), 150 mg bid (n=13) or 200 mg bid (n=3) (
); (C) Correlation analysis between Cmax and 7 different dose levels after multiple dose of fluzoparil (10−150 mg bid) at d 15; (D) Correlation analysis between AUC 0−10 h and 7 different dose levels after multiple dose of fluzoparil (0−150 mg bid) at d 15.
