1. Clinical characteristics of study population by biopsy types*.
| Variables | Abnormal colposcopy impression and up
to 4 targeted biopsies (N=1,606) |
Normal colposcopy impression and 4-quadrant
random biopsies (N=3,317) |
|||||
| Normal/CIN1
[n (%)] |
CIN2+ [n (%)] | χ2, P | Normal/CIN1
[n (%)] |
CIN2+ [n (%)] | χ2, P | ||
| *, 24 cases of CIN2+ found by endocervical curettage alone, 8 of them had lesion targeted biopsy and 16 of them had 4-quadrant random biopsy; **, 5 cases of unsatisfactory cytology were not listed; CIN, cervical intraepithelial neoplasia; NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; AGC, atypical glandular cells; ASC-H, atypical squamous cells, favor high grade; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; SCC, squamous cell carcinoma; HPV, human papillomavirus; VIA/VILI, visual inspection via acetic acid and Lugol’s iodine. | |||||||
| Age (year) | 32.74, <0.001 | 15.53, 0.001 | |||||
| ≤34 | 178 (87.7) | 25 (12.3) | 178 (92.2) | 15 (7.8) | |||
| 35−39 | 473 (79.8) | 120 (20.2) | 1,282 (96.2) | 50 (3.8) | |||
| 40−44 | 382 (75.6) | 123 (24.4) | 999 (94.6) | 57 (5.4) | |||
| ≥45 | 205 (67.2) | 100 (32.8) | 681 (92.5) | 55 (7.5) | |||
| Cytology** | 633.65, <0.001 | 690.59, <0.001 | |||||
| NILM | 720 (96.1) | 29 (3.9) | 1,877 (98.8) | 23 (1.2) | |||
| ASC-US | 234 (87.3) | 34 (12.7) | 721 (96.9) | 23 (3.1) | |||
| AGC | 6 (100) | 0 (0) | 15 (83.3) | 3 (16.7) | |||
| ASC-H | 5 (71.4) | 2 (28.6) | 7 (77.8) | 2 (22.2) | |||
| LSIL | 183 (72.3) | 70 (27.7) | 406 (90.8) | 41 (9.2) | |||
| HSIL | 85 (27.5) | 224 (72.5) | 109 (55.3) | 88 (44.7) | |||
| SCC | 0 (0) | 9 (100) | 1 (50.0) | 1 (50.0) | |||
| HPV | 176.71, <0.001 | 31.92, <0.001 | |||||
| Negative | 475 (98.3) | 8 (1.7) | 572 (99.5) | 3 (0.5) | |||
| Positive | 763 (67.9) | 360 (32.1) | 2,568 (93.7) | 174 (6.3) | |||
| VIA/VILI | 61.98, <0.001 | 9.35, 0.009 | |||||
| Normal | 510 (81.5) | 116 (18.5) | 2,738 (94.9) | 148 (5.1) | |||
| Abnormal | 728 (74.3) | 252 (25.7) | 402 (93.3) | 29 (6.7) | |||
| Colposcopy | 205.52, <0.001 | − | |||||
| Normal | 0 (0) | 0 (0) | 3,140 (94.7) | 177 (5.3) | |||
| LSIL | 1,096 (83.9) | 211 (16.1) | 0 (0) | 0 (0) | |||
| HSIL | 137 (51.7) | 128 (48.3) | 0 (0) | 0 (0) | |||
| Cancer | 5 (14.7) | 29 (85.3) | 0 (0) | 0 (0) | |||