2. Proportion of detected cases and yield of CIN2+ by biopsies numbers among females with abnormal colposcopy impression.
| Clinical diagnosis | Biopsy needed* | Lesion-targeted biopsy | Additional random biopsy | |||||||||
| CIN2+ (n) | Cumulative proportion (%) | 95% CI (%) | Cumulative CIN2+ yield | CIN2+ (n) | Cumulative proportion (%) | 95% CI (%) | Cumulative CIN2+ yield | |||||
| *, “Biopsy needed” describes that to detect one quadrant of CIN2+, the maximum number of lesion-targeted biopsy needed by quadrant, ranking order by the severity of colposcopy impression; **, 5 cases of unsatisfactory cytology and 6 cases of AGC were not listed here. HSIL+ including ASC-H, HSIL, and SCC; CIN, cervical intraepithelial neoplasia; NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; HPV, human papillomavirus; VIA/VILI, visual inspection via acetic acid and Lugol’s iodine; 95% CI, 95% confidence interval; ASC-H, atypical squamous cells, favor high grade; SCC, squamous cell carcinoma; AGC, atypical glandular cells. | ||||||||||||
| ALL (N=1,606) | 1 | 200 | 54.3 | 49.2 | 59.4 | 0.12 | 17 | 4.6 | 2.9 | 7.3 | 0.01 | |
| 1−2 | 288 | 78.3 | 73.8 | 82.2 | 0.18 | 28 | 7.6 | 5.3 | 10.8 | 0.02 | ||
| 1−3 | 318 | 86.4 | 82.5 | 89.5 | 0.20 | 30 | 8.2 | 5.8 | 11.4 | 0.02 | ||
| 1−4 | 338 | 91.8 | 88.6 | 94.2 | 0.21 | |||||||
| Cytology** | ||||||||||||
| NILM (N=749) | 1 | 15 | 51.7 | 34.4 | 68.6 | 0.02 | 1 | 3.4 | 0.6 | 17.2 | 0 | |
| 1−2 | 24 | 82.8 | 65.5 | 92.4 | 0.03 | 3 | 10.3 | 3.6 | 26.4 | 0 | ||
| 1−3 | 26 | 89.7 | 73.6 | 96.4 | 0.03 | 3 | 10.3 | 3.6 | 26.4 | 0 | ||
| 1−4 | 26 | 89.7 | 73.6 | 96.4 | 0.03 | |||||||
| ASC-US (N=268) | 1 | 13 | 38.2 | 23.9 | 55.0 | 0.05 | 5 | 14.7 | 6.5 | 30.1 | 0.02 | |
| 1−2 | 23 | 67.6 | 50.8 | 80.9 | 0.09 | 7 | 20.6 | 10.4 | 36.8 | 0.03 | ||
| 1−3 | 25 | 73.5 | 56.9 | 85.4 | 0.09 | 7 | 20.6 | 10.4 | 36.8 | 0.03 | ||
| 1−4 | 27 | 79.4 | 63.2 | 89.7 | 0.10 | |||||||
| LSIL (N=253) | 1 | 41 | 58.6 | 46.9 | 69.4 | 0.16 | 2 | 2.9 | 0.8 | 9.8 | 0.01 | |
| 1−2 | 55 | 78.6 | 67.6 | 86.6 | 0.22 | 4 | 5.7 | 2.2 | 13.8 | 0.02 | ||
| 1−3 | 58 | 82.9 | 72.4 | 89.9 | 0.23 | 4 | 5.7 | 2.2 | 13.8 | 0.02 | ||
| 1−4 | 66 | 94.3 | 86.2 | 97.8 | 0.26 | |||||||
| HSIL+ (N=325) | 1 | 131 | 56.2 | 49.8 | 62.4 | 0.41 | 9 | 3.9 | 2.0 | 7.2 | 0.03 | |
| 1−2 | 186 | 79.8 | 74.2 | 84.5 | 0.58 | 14 | 6.0 | 3.6 | 9.8 | 0.04 | ||
| 1−3 | 209 | 89.7 | 85.1 | 93.0 | 0.66 | 16 | 6.9 | 4.3 | 10.9 | 0.05 | ||
| 1−4 | 219 | 94.0 | 90.2 | 96.4 | 0.69 | |||||||
| HPV | ||||||||||||
| HPV− (N=483) | 1 | 8 | 100 | 67.6 | 100 | 0.02 | 0 | 0 | 0 | 0 | 0 | |
| 1−2 | 8 | 100 | 67.6 | 100 | 0.02 | 0 | 0 | 0 | 0 | 0 | ||
| 1−3 | 8 | 100 | 67.6 | 100 | 0.02 | 0 | 0 | 0 | 0 | 0 | ||
| 1−4 | 8 | 100 | 67.6 | 100 | 0.02 | |||||||
| HPV+ (N=1,123) | 1 | 192 | 53.6 | 48.2 | 58.4 | 0.17 | 17 | 4.7 | 3.0 | 7.4 | 0.02 | |
| 1−2 | 280 | 77.8 | 73.2 | 81.8 | 0.25 | 28 | 7.8 | 5.4 | 11.0 | 0.02 | ||
| 1−3 | 310 | 85.8 | 82.2 | 89.3 | 0.28 | 30 | 8.3 | 5.9 | 11.7 | 0.03 | ||
| 1−4 | 330 | 91.7 | 88.4 | 94.1 | 0.29 | |||||||
| VIA/VILI | ||||||||||||
| Normal (N=626) | 1 | 62 | 53.4 | 44.4 | 62.3 | 0.10 | 7 | 6.0 | 3.0 | 11.9 | 0.01 | |
| 1−2 | 88 | 75.9 | 67.3 | 82.7 | 0.14 | 14 | 12.1 | 7.3 | 19.2 | 0.02 | ||
| 1−3 | 97 | 83.6 | 75.8 | 89.3 | 0.15 | 14 | 12.1 | 7.3 | 19.2 | 0.02 | ||
| 1−4 | 102 | 87.9 | 80.8 | 92.7 | 0.16 | |||||||
| Abnormal
(N=980) |
1 | 138 | 54.8 | 48.6 | 60.8 | 0.14 | 10 | 4.0 | 1.6 | 6.4 | 0.01 | |
| 1−2 | 200 | 79.4 | 74.0 | 83.9 | 0.20 | 14 | 5.6 | 2.7 | 8.4 | 0.01 | ||
| 1−3 | 221 | 87.7 | 83.1 | 91.2 | 0.23 | 16 | 6.3 | 3.3 | 9.4 | 0.02 | ||
| 1−4 | 236 | 93.7 | 89.9 | 96.1 | 0.24 | |||||||
| Colposcopy | ||||||||||||
| LSIL (N=1,307) | 1 | 103 | 48.8 | 42.2 | 55.5 | 0.08 | 16 | 7.6 | 3.9 | 10.1 | 0.01 | |
| 1−2 | 154 | 73.0 | 66.6 | 78.5 | 0.12 | 25 | 11.8 | 6.8 | 14.2 | 0.02 | ||
| 1−3 | 176 | 83.4 | 77.8 | 87.8 | 0.13 | 27 | 12.8 | 7.5 | 15.1 | 0.02 | ||
| 1−4 | 184 | 87.2 | 82.0 | 91.1 | 0.14 | |||||||
| HSIL+ (N=299) | 1 | 97 | 61.8 | 54.0 | 69.0 | 0.32 | 1 | 0.6 | 0.1 | 3.5 | 0 | |
| 1−2 | 134 | 85.4 | 79.0 | 90.0 | 0.45 | 3 | 1.9 | 0.7 | 5.5 | 0.01 | ||
| 1−3 | 142 | 90.4 | 84.8 | 94.1 | 0.47 | 3 | 1.9 | 0.7 | 5.5 | 0.01 | ||
| 1−4 | 154 | 98.1 | 94.5 | 99.4 | 0.52 | |||||||
| Age (year) | ||||||||||||
| ≤34 (N=203) | 1 | 14 | 56.0 | 37.1 | 73.3 | 0.07 | 0 | 0 | 0 | 0 | 0 | |
| 1−2 | 19 | 76.0 | 56.6 | 88.5 | 0.09 | 2 | 8.0 | 2.2 | 25.0 | 0.01 | ||
| 1−3 | 22 | 88.0 | 70.1 | 95.8 | 0.11 | 2 | 8.0 | 2.2 | 25.0 | 0.01 | ||
| 1−4 | 23 | 92.0 | 75.0 | 97.8 | 0.11 | |||||||
| 35−39 (N=593) | 1 | 55 | 45.8 | 37.2 | 54.7 | 0.09 | 3 | 2.5 | 0.9 | 7.1 | 0.01 | |
| 1−2 | 95 | 79.2 | 71.1 | 85.5 | 0.16 | 5 | 4.2 | 1.8 | 9.4 | 0.01 | ||
| 1−3 | 105 | 87.5 | 80.4 | 92.3 | 0.18 | 6 | 5.0 | 2.3 | 10.5 | 0.01 | ||
| 1−4 | 114 | 95.0 | 89.5 | 97.7 | 0.19 | |||||||
| 40−44 (N=505) | 1 | 72 | 58.5 | 49.7 | 66.9 | 0.14 | 11 | 8.9 | 5.1 | 15.3 | 0.02 | |
| 1−2 | 92 | 74.8 | 66.5 | 81.6 | 0.18 | 15 | 12.2 | 7.5 | 19.2 | 0.03 | ||
| 1−3 | 103 | 83.7 | 76.2 | 89.2 | 0.20 | 15 | 12.2 | 7.5 | 19.2 | 0.03 | ||
| 1−4 | 108 | 87.8 | 80.9 | 92.5 | 0.21 | |||||||
| ≥45 (N=305) | 1 | 59 | 59.0 | 49.2 | 68.1 | 0.19 | 3 | 3.0 | 1.0 | 8.5 | 0.01 | |
| 1−2 | 82 | 82.0 | 73.3 | 88.3 | 0.27 | 6 | 6.0 | 2.8 | 12.5 | 0.02 | ||
| 1−3 | 88 | 88.0 | 80.2 | 93.0 | 0.29 | 7 | 7.0 | 3.4 | 13.8 | 0.02 | ||
| 1−4 | 93 | 93.0 | 86.3 | 96.6 | 0.30 | |||||||