Table 1.
Risk factors for human papillomavirus (HPV) -positive nonoropharyngeal (HPV-nonOPC) compared with matched controls, and with HPV-oropharyngeal cancer (HPV-OPC).
| HPV-nonOPC N=20 | Matched controls N=80 | HPV-nonOPC cases vs. controls | HPV-OPC N=185 | HPV-nonOPC vs. HPV-OPC | |
|---|---|---|---|---|---|
| N (%) | N (%) | OR (95% CI) | N (%) | OR (95% CI) | |
| History of tonsillectomy | 3 (50) | 26 (42) | 2.05 (0.19–22.0) | 42 (45) | 1.24 (0.24–6.5) |
| Excellent/very good oral hygiene | 11 (69) | 40 (53) | 2.04 (0.57–7.4) | 97 (57) | 1.67 (0.56–5.0) |
| Obese | 3 (19) | 19 (26) | 0.64 (0.17–2.5) | 44 (26) | 0.67 (0.18–2.5) |
| Sexual exposure | |||||
| Age at sexual debut <18 | 9 (60) | 25 (35) | 2.79 (0.89–8.7) | 109 (65) | 0.80 (0.27–2.4) |
| Ever oral sex | 13 (87) | 60 (81) | 2.79 (0.35–10.8) | 166 (99) | 0.08 (0.01–0.6) |
| >3 lifetime oral sex partners | 7 (47) | 35 (47) | 0.88 (0.23–3.3) | 126 (75) | 0.29 (0.06–0.9) |
| >3 lifetime vaginal sex partners | 10 (77) | 42 (63) | 1.34 (0.32–5.5) | 148 (93) | 0.27 (0.10–1.1) |
| Substance use | |||||
| Ever tobacco use | 16 (80) | 40 (51) | 3.49 (1.11–10.9) | 100 (55) | 3.28 (1.10–10.2) |
| >10 pack years | 9 (60) | 5 (11) | 18.88 (2.34–152.6) | 43 (29) | 3.66 (1.23–10.9) |
| >30 year cigarette use | 9 (64) | 7 (12) | 7.49 (1.97–28.4) | 25 (19) | 7.78 (2.40–25.2) |
| Alcohol use ≥15 days/month | 9 (45) | 38 (48) | 0.91 (0.34–2.4) | 68 (37) | 1.41 (0.56–3.6) |
| Regular marijuana use | 5 (50) | 21 (49) | 0.40 (0.06–2.7) | 47 (36) | 1.79 (0.49–6.5) |
| >10 pot years | 1 (14) | 8 (18) | 0.78 (0.07–8.9) | 28 (36) | 0.30 (0.03–2.6) |
| Ever cocaine/heroin/ methamphetamine use |
4 (29) | 15 (21) | 1.40 (0.39–5.0) | 56 (34) | 0.79 (0.24–2.6) |